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KMID : 0604520140400010089
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Journal of the Society of Cosmetic Scientists of Korea
2014 Volume.40 No. 1 p.89 ~ p.94
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Depigmenting Effects of Esculetin and Esculin Isolated from Fraxinus rhynchophyllaHance
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Hong Yong-Deog
Nam Mi-Hee
Lee Chang-Suk
Shin Song-Seok
Park Young-Ho
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Abstract
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Stem bark extracts of Fraxinus rhynchophylla Hance were found to contain two major bioactive components,esculetin and esculin. Esculetin substantially inhibited melanogenesis in B16F10 melanoma cells, with an IC50 value of2.8 μm, and reduced melanin synthesis in Melan-A cells. Moreover, esculetin suppressed melanin biosynthesis by inhibitingmushroom tyrosinase activity, with an IC50 value of 40 μM. Taken together, these results suggest that esculetincould serve as an effective skin-lightening agent that inhibits melanin production by regulating the activity of melanogenicenzymes.
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KEYWORD
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Fraxinus rhynchophylla Hance, melanogenesis, tyrosinase, esculetin, esculin
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